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To propel a spacecraft in the direction leaving the Sun, a magnetic sail (MagSail) blocks the hypersonic solar wind plasma flow by an artificial magnetic field. In order to simulate the interaction between the solar wind and the artificially deployed magnetic field produced around a magnetic sail spacecraft, a laboratory simulator was designed and constructed inside a space chamber. As a solar wind simulator, a high-power magnetoplasmadynamic arcjet is operated in a quasisteady mode of 0.8 ms duration. It can generate a simulated solar wind that is a high-speed (above 20 km/s), high-density (10 18 m −3 ) hydrogen plasma plume of ∼0.7 m in diameter. A small coil (2 cm in diameter), which is to simulate a magnetic sail spacecraft and can obtain 1.9-T magnetic field strength at its center, was immersed inside the simulated solar wind. Using these devices, the formation of a magnetic cavity (∼8 cm in radius) was observed around the coil, which indicates successful simulation of the plasma flow of a MagSail in the laboratory.

Natural killer (NK) cells can be cultured in interleukin-2 (IL-2)- containing medium from selected human bone marrow (BM) cells obtained after the elimination of mature T and NK cells. To isolate and characterize IL-2-responsive NK progenitors in the selected BM cells, we investigated the expression of IL-2 receptors (IL-2R) on these cells. Neither CD25 (IL-2R alpha) nor IL-2R beta antigen was observed on the selected BM cells before culture. However, CD25+ cells without detectable levels of IL-2R beta antigen appeared 24 hours after culture in IL-2-containing medium. Cells were sorted from each fraction of the selected BM cells 24 hours after culture after staining with anti-CD33, anti-CD34, and anti-CD25 monoclonal antibodies. The generation of NK cells (CD3- CD56+ cells) and NK activity were observed only from the CD33-/CD34-/CD25+ cell fraction after culture in IL-2-containing medium. The frequency of IL-2-responsive NK progenitors relative to the fraction was 1/231 (95% confidence range, 1/156 to 1/289), which corresponded to the frequency relative to the total number of selected BM cells when the frequency relative to the CD33-/CD34-/CD25+ cell- fraction was converted according to the percentage of these cells in the total number of selected BM cells. These results indicated that IL- 2-responsive NK progenitors were enriched in the CD33-/CD34-/CD25+ cell fraction.

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