Purpose To corroborate the factor structure of the brief Spanish Zung Self‐Rating Depression Scale among patients with chronic pulmonary obstructive disease at Santa Marta, Colombia. Design and Methods A psychometric study was done in which 409 patients with the chronic obstructive pulmonary disease were included, aged between 40 and 102 years. Participants completed the 10 items on the brief Spanish Zung Self‐Rating Depression Scale. Confirmatory factor analysis was performed. Findings The two‐dimensional structure was confirmed. The goodness of fit indicators was acceptable. Practical Implication The brief Spanish Zung scale for depression has a clear two‐dimensional structure for evaluating depressive symptoms in patients with chronic obstructive pulmonary disease. New studies should prove this dimensionality in patients with other clinical conditions.