Introduction: Urolithiasis is a complex process that occurs from series of several physicochemical event including super-saturation, nucleation, growth, aggregation and retention within the kidneys. Data from invitro, in- vivo and clinical trials reveal that phytotherapeutic agents could be useful as either alternative or an adjunct therapy in the management of Urolithiasis. Scoparia dulcis (L.) have been reported to possess antiurolithiatic property by various folk lore practitioners. Methods: The in- vitro antiurolithiatic study of the whole plant of S. dulcis (L). through titrimetric and turbidity method to check their potential in dissolving calcium oxalate crystals using Cystone as the standard compound Result: The aqueous extract showed relatively higher dissolution of 66.96% of stones than the alcoholic extract. The turbidity showed by the alcohol extract and the aqueous extract of test drug (S. dulcis (L).) was highly significant compared to the standard (Cystone)

Introduction: Scoparia dulcis Linn. locally known as Manithumbe Gida belongs to Scophularaceae family and used in medicine by the traditional practitioners for the treatment of urinary calculi. Materials and Methods: Matured plants are collected from Udupi district and authenticated. Macro-microscopic features, physico-chemical standards, HPTLC and secondary metabolites were recorded as per standard guidelines. Result: TS of leaf has shown the presence of mesophyll and bi-collateral vascular bundles. Outer cork tissue, a layer of cortex and conjoint collateral closed vascular bundles and central pith are inclusions of stem TS. Pitted and reticulate vessels are characteristic features of plant powder. Physico-chemical standards and presence of alkaloids, carbohydrates, tannin and coumarins were indicative of its chemical nature. HPTLC fingerprints are a record of its different chemical constituents. Thus the quality monograph prepared on this drug beneficial in future research.