This review highlights the application of intramolecular Heck reaction in total synthesis of natural products which were successfully synthesized in recent years (2013 to 2019). Heck cyclization was used as one of the strategic steps for constructions of wide variety of cyclic scaffolds essential for preparation of different natural products.

Stereoselective total synthesis of structurally intriguing polyketide natural product thailandamide lactone has been accomplished for the first time adopting a convergent approach. The key feature of this synthesis includes Crimmins...