Highlights d Proline synthesis through PYCR1 is increased in low-oxygen conditions d PYCR1 activity in hypoxia supports TCA cycle function through NADH oxidation d PYCR1 is required for maintenance of hypoxic tumor regions

Vehicular Ad hoc Networks (VANET) exhibit highly dynamic behavior with high mobility and random network topologies. The performance of Transmission Control Protocols in such wireless ad hoc networks is plagued by a number of problems: frequent link failures, scalability, multi-hop data transmission and data loss. To address these VANET routing issues, I have used the ideas from swarm intelligence.The Ant Colony Optimization (ACO), which is a branch of swarm intelligence, is the main source of my inspiration. I have designed an ant-based routing algorithm which addresses routing issues prevalent in VANETs: adaptivity, robustness and scalability. One attractive feature of ACO is that they provide multiple routes from source to destination, resulting in more robust network. In this work, together with ACO, I have used the ideas from zone routing protocols to develop my algorithm: Mobility Aware Zone based Ant Colony Optimization Routing for VANET that exhibits locality and scalability.ii

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Pradesh and West Bengal. In India, total production of tomato is approximately 18.74 million tonnes from an area about 0.88 million hectares with an average productivity of 16.1 metric tonnes per hectare (Anonymous, 2015). Rajasthan contributes about 7.52 million tonnes productions with an area of 0.16 million hectares and productivity of 4.5 metric tonnes per hectare. The major tomato growing districts of Rajasthan are Jaipur, Alwar, Tonk,