Acute myeloid leukemia (AML) is an immensely heterogeneous disease characterized by the clonal growth of promyelocytes or myeloblasts in bone marrow as well as in peripheral blood or tissue.Enhancement in the knowledge of the molecular biology of cancer and recognition of intermittent mutations in AML contribute to favorable circumstances to establish targeted therapies and enhance the clinical outcome. There is high interest in the development of therapies that target definitive abnormalities in AML while eradicating leukemia-initiating cells. In recent years, there has been a better knowledge of the molecular abnormalities that lead to the progression of AML, and the application of new methods in molecular biology techniques has increased that facilitating the advancement of investigational drugs.In this review, literature or information on various gene mutations for AML is discussed. English language articles were scrutinized in plentiful directories or databases like PubMed, Science Direct, Web of Sciences, Google Scholar, and Scopus. The important keywords used for searching databases is “Acute myeloid leukemia”, “Gene mutation in Acute myeloid leukemia”, “Genetic alteration in Acute myeloid leukemia,” and “Genetic abnormalities in Acute myeloid leukemia.”

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To assess and compare anteroposterior jaw dysplasia indicators i.e. (Wits-appraisal, ANB-angle, β(Beta)-angle, W-angle, YEN-angle and π(Pi)-angle) in Angle's Class I molar relation subjects with normal overjet of central India.Sum of 40 lateral cephalograms were traced in line with the inclusion criteria of Angle’s Class I molar relation subjects. Subjects had to be between the ages of 18 and 30 and have a normal overjet and aligned arches. We measured and compared the Wits-appraisal, ANB-angle, (Beta)-angle, W-angle, YEN-angle and Pi-angle. The statistical package for social sciences (SPSS) 20.0 version was used to examine the data. We used descriptive statistics. The Spearman's correlation coefficient was used to evaluate the correlation between the variables. Statistics were judged as significant at a p-value of 0.05. 95% of the confidence interval was chosen. The result showed descriptive statistical representation for the norms of Wits-appraisal, ANB-angle, Beta-angle, Yen-angle, W-angle, and Pi-angle for the Central India population. We found a high correlation of ANB-angle with YEN-angle, ANB-angle and Pi linear, ANB-angle and W-angle, Beta-angle and W-angle, YEN-angle and W-angle and Pi-angle and Pi linear. Among the angles used for the comparative evaluation for the prediction of anteroposterior jaw dysplasia, W-angle and YEN-angle had the utmost accuracy, whereas Beta-angle had the least. Therefore, YEN-angle and W-angle are reliable in our practice in the prediction of anteroposterior jaw dysplasia in the Central India population.

To determine the soft tissue angular photogrammetric standards in Central Indian topics.40 central Indian participants, 20 males and 20 females, ranging in age from 18 to 25, were examined in this study using lateral profile photographs Standardized profile pictures were obtained between the focal lengths of 55 and 200 mm with a camera Canon 1500D macro lens. The data were analysed using SPSS 20.0, a statistical software for social sciences. Using the Kolmogorov-Smirnov test to determine the probability distribution of the data, it was determined that the data were not normally distributed (p value.05).The present study used photogrammetric analysis to develop soft tissue face measures that will help orthodontists undertake more quantitative analysis and reach informed conclusions. By using this photogrammetric approach, the collected mean values may be compared to records of persons who had the same characteristics. There were statistically significant variations in Central India for a few key parameters.