Hyperlipidemia is the major risk factor of arteriosclerosis, coronary heart diseases and death. Phenolic compounds have been shown to offer the protection against cardiovascular complications. In the present study, we studied the effect of semisynthetic phenolic compounds on the hyperlipidemic mice fed with high fat diet (cholesterol, cholic acid and peanut oil). Phenolic compounds were mixed with HFD and the dose of the test compounds were 1 0mg/kg for 6 weeks. After 6 weeks, the average body weight of lab diet, HFD, standard and test compounds were evaluated. Average body weight of test compound 1, test compound 2 and test compound 3 showed insignificant results (P>1) as compared to the standard drug (Atorvastatin in this study). The liver weight of mice increased (P>1) in all treatment groups relative to standard drug fed group. The plasma lipids such as triglyceride and LDL-cholesterol were found to be increased (P>1) in Test compound 1, test compound 2 , test compound 3 and HFD fed mice when compared to that of standard drug ( Atorvastatin) fed mice. But high-density lipoprotein (HDL) cholesterol increased in standard when compared to that of lab diet fed mice, HFD and test compounds. In conclusion, the supplementation of semi synthetic phenolic compounds may have a weak potential of hypolipidemic effect on mice fed high-fat diet.

It is seen that most of the deaths are occurring due to diseases of cardiovascular system. There is a significant impact of lifestyle changes on the quality of health. Utilization of food highly rich with saturated fat and having low fiber content is one of the factors of disarray in energy balance. It is now evinced that hyperlipidemia is depicted as a major risk factor for the premature development of atherosclerosis and its cardiovascular complications. The prevalence of obesity has doubled in the past 25 years; today, two-thirds of adults are overweight in the United State [1].

In industrial process control, fluid level control is one of the most basic aspects. Many control methods such as on-off, linear and PID (Proportional Integral Derivative) were developed time by time and used for precise controlling of fluid level. Due to flaws of PID controller in non-linear type processes such as inertial lag, time delay and time varying etc., there is a need of alternative design methodology that can be applied in both linear and non-linear systems and it can be execute with fuzzy concept. By using fuzzy logic, designer can realize lower development cost, superior feature and better end product. In this paper, level of fluid in tank is control by using fuzzy logic concept. For this purpose, a simulation system of fuzzy logic controller for fluid level control is designed using simulation packages of MATLAB software such as Fuzzy Logic Toolbox and Simulink. The designed fuzzy logic controller first takes information about inflow and outflow of fluid in tank than maintain the level of fluid in tank by controlling its output valve. In this paper, a controller is designed on five rules using two-input and one-output parameters. At the end, simulation results of fuzzy logic based controller are compared with classical PID controller and it shows that fuzzy logic controller has better stability, fast response and small overshoot.

No abstract

This study is important due to the long terms negative effects of using stimulants for ADHD therapy as they manifest negative side effects. The amphetamine stimulants are neurotoxic with long-terms use and it's imperative to use it in lower dosages while at the same time yielding the maximum affects to treat ADHD symptoms. This narrative review is conducted to explore the professional literature between 2000-2015. The trials conducted to explore the efficacy of adjunctive therapy with stimulants demonstrated various results. The supplementation of combined magnesium and vitamin B6 yielded positive results with significant improvement in ADHD, specifically in hyperactivity, aggression, and low attention span. Zinc supplementation, with 30 mg or more, with amphetamine aided in lowering the dosage of amphetamine use by at least 20% while yielding the same results compared to higher amphetamine use without zinc. Zinc+methylphenidate combination yielded positive results to lower ADHD symptoms; however the results are not conclusive due to more trials are needed in different dosages of zinc. Based on the clinical studies, dietary supplements are useful in treating ADHD symptoms. Clinical trials with zinc and magnesium+B6 have shown to yield positive results in lowering the ADHD symptoms. With current ADHD therapy, continued stimulant use leads to tolerance and increases with continued use; hence the stimulant dosage also needs to be increased to reach efficacy. Adding adjunctive dietary supplements have demonstrated that the