This research includes synthesis and characterization of some homogeneous binuclear complexes of Co(II), Ni(II), and Pd(II) with mixed ligands of thiuram, uracil thiuram disulfur or thymine thiuram disulfur, and cyclic amines. The formed complexes have the general formula of [M2(L)1(amin)2] where L = (thymine thiuram disulfur), (uracil thiuram disulfur) = (T‐TDS), (U‐TDS), amin = (1,10‐Phen.) (2,2′‐BiPy.), and M = Co(II), Ni(II), Pd(II). The synthesized complexes are characterized using the micro‐elemental analysis (C.H.N.S), electrical molar conductivity, magnetic sensitivity, and spectra methods (UV–Vis, IR and 1H NMR, 13C‐{1H}NMR). Antibacterial activity of ligands and complexes is evaluated with two types of bacteria Staphylococcus aurous (gram‐positive) and Escherichia coli (gram‐negative). According to the results obtained from physical and spectroscopic measurements, the complexes of cobalt(II) and nickel(II) have tetrahedral geometry and the palladium(II) complexes are square planar.