There are many kinds of dumbbell-shaped spinal tumors other than neurogenic ones. MRI is useful in diagnosing dumbbell-shaped spinal tumors, especially those of neurogenic origin, and aids in distinguishing benign from malignant tumors.
A 60-year-old woman suffered from recurrent episodes of fever, hypertension, facial flushing, vomiting, stridor, slowly progressive symptoms of hypohidrosis, and orthostatic hypotension. The episodes were synchronous with elevated catecholamine concentration in plasma and urine. This is an example of paroxysmal autonomic hyperreflexia in a setting of pure progressive autonomic failure.
Tumor detection with 11C‐1‐aminocyclopentane carboxylic acid (11‐ACPC) showed that this amino acid has a high affinity for malignant tumors. We studied the kinetics of intravenously injected 11C‐ACPC in the rabbit VX‐2 tumor using positron emission tomography. Three female rabbits bearing VX‐2 tumor in the thighs were used. High uptake of 11C‐ACPC was seen in the tumor and liver. 11‐ACPC in plasma decreased rapidly after injection and its activity in the tumor increased with time. The kinetic evaluation of ACPC uptake into the tumor was performed using the unidirectional transport model. The average values of the transfer constant of 11C‐ACPC for VX‐2 tumor were 0.030±0.002 ml/min/g. This preliminary result may form the basis for a quantitative analysis of the in vivo distribution of 11C‐labeled ACPC in tumors.
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