Synthesis of the epimer of pericosine B from (؊)-quinic acid was achieved. This synthesis involves some regioselective and stereoselective processes. The desired product showed lower cytotoxic activity in comparison with natural pericosine B against the P388 leukemia cell line. The result implies that the stereocenter of C-6 in natural pericosine B plays an important role in this activity.

Synthesis of the Epimer of Pericosine B from (-)-Quinic Acid. -A stereoselective synthesis of the C-6 epimer of pericosine B is presented. The cytotoxic activity of this epimer (I) is lower than that of pericosine B. -(USAMI*, Y.; HATSUNO, C.; YAMAMOTO, H.; TANABE, M.; NUMATA, A.; Chem.