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Adsorptionkinetics of amino-terminated po!y(amido amine) dendrimer (PAMAM) and poly(trimethyleneimine) dendrimer (PTMI) from aqueous solutions onto 3-mercaptopropionic acid (MPA) self-assembled monolayer (SAM) on Au films have been investigated by surface plasmon resonance sensor and surface enhanced infrared absorption spectroscopy. The adsorption kinetics at high dendrimer concentrations does not obey Langmuir adsorption mechanism but passes 2-step adsorption process, which includes monolayer adsorption and additional adsorption on it. Further consideration indicates the difference on the adsorption structure between two dendrimers: PAMAM dendrimer adsorbs with "the hemi-micellar structure" because of the electrostatic and hydrogen-bonding interactions between amine of PAMAM and carboxylate of MPA SAM, while the adsorption structure of PTMI dendrimer is "the hourglass type" or "the conical type" due to no hydrogen-bonding interaction between dendrimer interior and MPA SAM.

2+ , a channel blocker of the NMDA receptor, reduced the large holding currents needed for mutant NMDA receptors. These data indicate that ATGDMAP 1 directly acts on the channel pores of the NMDA receptor.