Hiroko Yamaura scite author profile

The endothelium-dependent relaxation of superior mesenteric arteries of Wistar and genetically diabetic WBN/Kob rats was compared. Endothelium-dependent relaxation induced by acetylcholine (ACh) and A23187 was depressed in WBN/Kob rats. Relaxation induced by sodium nitroprusside, an endothelium-independent agent, in strips from WBN/Kob rats was similar to that in strips from Wistar rats. Indomethacin (5 x 10(-6) M) enhanced the relaxation responses to ACh in strips from both WBN/Kob and Wistar rats; however, endothelium-dependent relaxation induced by ACh remained attenuated in WBN/Kob rats. These results show that endothelium-dependent relaxation is impaired not only in thoracic aorta but also in superior mesenteric arteries in genetically diabetic rats.

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Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: A study in WBN/KOB rats

Miyata

Yamaura²,

Tsuchida³

et al. 1992

Life Sciences

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Effects of VA-045, a novel apovincaminic acid derivative, on isolated blood vessels: Cerebroarterial selectivity

et al. 1993

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Hiroko Yamaura

Decreased contractile effect of endothelin-1 on hyperplastic prostate

Multidirectional contraction of human hypertrophied prostate

Impairment of endothelium-dependent relaxation of superior mesenteric artery in genetically diabetic WBN/Kob rats

Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: A study in WBN/KOB rats

Effects of VA-045, a novel apovincaminic acid derivative, on isolated blood vessels: Cerebroarterial selectivity

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