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We propose a simple method to correct a large amount of spherical aberration caused by a refractive index mismatch. The method is based on inverse ray tracing and can generate correction phase patterns whose peak-to-valley values are minimized. We also demonstrated spherical aberration correction in a transparent acrylic block using a liquid-crystal-on-silicon spatial light modulator (LCOS-SLM). A distorted focal volume without correction was substantially improved with correction. This method is useful in cases where a large phase modulation is needed, such as when employing a high-NA lens or focusing a beam deep inside a sample.

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Magnetic resonance (MR) imaging was performed in eight healthy volunteers and 30 patients with histologically and endocrinologically proved thyroid diseases. The use of a surface coil greatly improved spatial resolution, and normal anatomic structures were well demonstrated. In thyroid tumors, the margin, pseudocapsule, and lymph nodes were easily detected. Smooth margins, lobulated margins, and pseudocapsules were found in both adenoma and papillary carcinoma, whereas unclear margins were found only in papillary carcinoma. An unclear margin between the tumor and adjacent normal thyroid tissue seemed to reflect an ill-defined tumor border on gross pathologic examination. Metastatic lymph nodes as small as 3 mm were seen. Identification of small vessels enabled detection of dilated vessels in thyroid parenchyma in patients with Graves disease. Hemorrhage (hemorrhagic degeneration) was often found in adenoma, papillary carcinoma, and adenomatous goiter, resulting in variable signal intensity.