Background: PPA binds to specific glycoprotein N-glycans. Results: Interaction between PPA and glycoligands in duodenum BBM activates glucose production while inhibiting glucose absorption by enterocytes. Conclusion: N-Glycans in BBM function as a target for ␣-amylase in order to control glucose assimilation via their interaction. Significance: We have discovered the modulatory role of BBM glycoprotein N-glycans, which contribute to blood glucose homeostasis.

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