1 Pharmacological eects of a novel opioid receptor-like1 (ORL 1 ) receptor antagonist, [N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) benzamide monohydrochloride] (JTC-801), were examined in in vitro and in vivo. We have demonstrated that JTC-801 antagonizes the ORL 1 receptor response, and that JTC-801 has ecacious and potent anti-nociceptive eects in acute pain animal models not only by intravenous injection but also oral administration. These results suggest that JTC-801 may represent a new class of analgesics.

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