Using an autoimmune hepatitis model of A/J mice which was prepared with immunization by syngeneic crude liver proteins, various influences of neonatal thymectomy were studied by observations of histological liver changes, autoantibody to liver-specific membrane lipoprotein (LSP), delayed-type hypersensitivity (DTH) to LSP, and purified protein derivative (PPD), and suppressor activity to LSP. The liver changes in the thymectomized mice were more intense than those in the non-thymectomized controls. Production of the anti-LSP autoantibodies and positive DTH to syngeneic LSP could be recognized in both groups of the thymectomized mice and the non-thymectomized controls, but the levels of those were higher in the former. In the level of DTH to PPD the thymectomized mice were lower than the non-thymectomized controls. Adoptive transfer experiments showed that suppressor activity to LSP was reduced in the spleen cells of neonatally thymectomized mice. This experiment suggests that neonatal thymectomy is apt to abolish tolerance to LSP on account of depressed suppressor activity to autoantigen, and accordingly liver damage is increased Keywords experimental hepatitis liver-specific membrane lipoprotein neonatal thymectomy suppressor cells

The liver involvement by tuberculosis in the macronodular form is quite rare and one must know their clinical features and actual imaging to have precise diagnosis. We present a case of the solitary hepatic tuberculosis, of which angiographic findings originally suggested hepatocellular carcinoma (HCC) given Lipiodol Ultra Fluid (LUF). On angiogram the tuberculoma showed marked hypervascularity in a capillary phase. Histological examination of the biopsy specimen disclosed gramulomas with central coagulation necrosis. A good clinical response was achieved with a course of Isoniazid and Rifammpicin. Angiographic findings of one year later showed hypovascularity. Meanwhile LUF remained long in the tuberculoma marginally, presenting nodular opacities on lipiodolized CT. This finding was different from that of HCC. Wealso discussed those clinical actual imaging and pathological findings.

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The present study examined correlations between state of free amino acids and hematological or plasma biochemistry, using blood samples acquired from Japaneseblack calves within 24 hours after birth. All of free amino acids demonstrated negative correlations with red blood cell counts, hemoglobins and hematocrits. The most significant positive correlation was recorded between γ-glutamyl transpeptidase and glutamic acid, with a linear regression of y=0.025 x+39.99, where x corresponds to γ-glutamyl transpeptidase and y corresponds to glutamic acid (r=0.88, p<0.001). This suggests glutamic acid concentration may relate to the degree of colostrum intake in Japanese-black newborn calves.

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