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Busulfex ® is a non-aqueous injection of insoluble Busulfan dissolved in the oil-based solvents Polyethylene Glycol 400 (PEG400) and N,N-Dimethylacetamide (DMA). The use of a closed system transfer device (CSTD) is strongly recommended for the preparation of all hazardous drugs, and we use a CSTD for the preparation and administration of anticancer drugs at Nara Medical University Hospital. We experienced a case of frequent blockage of the intravenous route when Busulfex ® was administered. In the present study, when the test solution containing PEG400 and DMA mixed in the same ratio as Busulfex ® was syringe aspirated by CSTD, the CSTD was broken and foreign particles were generated within 3 minutes of aspiration. When DMA was syringe aspirated by CSTD, polycarbonate, the material of CSTD, was eluted, and functional abnormality of CSTD was observed 30 minutes after aspiration. Oil-based solvents are used as additives in many anticancer drugs. The suitability of a CSTD for the preparation of anticancer drugs should be determined by considering not only the hazard classi cation of the anticancer drug, but also the type and ratio of the additives.