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Long-term effects of allogeneic bone marrow transplantation (ABMT) across major histocompatibility complex barriers were studied in (NZB X NZW)F1 (B/W), BXSB (6). From experiments with >100 mice using renal biopsies, autopsy analyses, and immunologic studies before and after allogeneic bone marrow transplantation (ABMT), we show herein that ABMT ameliorates established lupus nephritis in B/W mice and BXSB mice. In addition, long-term observation (from >5 mo to 1 yr post-ABMT) revealed that autoimmune diseases of BXSB and B/W mice often remained corrected for at least 1 yr after ABMT. By contrast, in MRL/lpr mice treated by ABMT from BALB/c donors, relapse of autoimmune disease regularly occurred -5 mo after ABMT. MATERIALS AND METHODSMice. MRL/lpr, NZB, BXSB, and NZW mice obtained from The Jackson Laboratory were maintained under specific pathogen-free conditions in the animal facility

ABSTRACT. Reproductive diseases after parturition are a serious problem in dairy cattle. It is important to predict postpartum reproducti ve diseases early and to develop prophylaxis. The objectives of this study were to demonstrate changes in the peripheral blood con centration of interleukin-6 (IL-6) before parturition, which was mainly produced by T helper 2 type (Th2) cells, and to investigate a correlation between the IL-6 concentration and the occurrence of the postpartum retained placenta, endometritis and/or follicular cyst in da iry cattle. Twenty-seven Holstein-Friesian cows were used for this study. Thirteen had no clinical disease, 8 had retained placenta, 4 were diagnosed with endometritis by vaginal inspection, and 2 were diagnosed with follicular cyst by rectal palpation at 1 and 2 months a fter parturition. Blood samples were collected 60 days pre-and post-partum. They used for IL-6, progesterone (P 4 ) and estradiol-17β (E 2 ) concentration determination. This study showed that the IL-6 concentration prepartum was higher than postpartum. Low levels of IL-6 and P 4 in peripheral blood prepartum tended to affect retained placenta and a high level of IL-6 prepartum tended to affect endometrit is. These results indicate that measurement of change in the IL-6 concentration during pregnancy is one useful tool for predicting crisis in postpartum reproductive diseases in dairy cattle. KEY WORDS: cattle, endometritis, interleukin-6, pregnant, retained placenta.

Magnetic resonance imaging examination provides useful data for prognostic assessment and planning strategies with which to treat oral tongue carcinoma. The preoperative decision as to whether to attempt neck dissection could be based on a tumor thickness of 6 mm for patients with oral tongue carcinoma.

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