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Gomisin A, isolated from the fruits of Schisandra chinensis, is one of the dibenzocyclooctadiene lignans. Application of 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 μg/ear), a tumor-promoting agent, to the ears of mice induces inflammation. Among seven dibenzocyclooctadiene lignans assayed, gomisin A, gomisin J, and wuweizisu C inhibited the inflammatory activity induced by TPA in mice. The ED₅₀ of these compounds for TPA-induced inflammation was 1.4–4.4 μmol. Gomisin A, with an ED₅₀ of 1.4 μmol, showed the strongest inhibitory effect. Furthermore, at 5 μmol/mouse, it markedly suppressed the promotion effect of TPA (2.5 μg/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 μg/ mouse). It is assumed that the inhibition of tumor promotion by gomisin A is due to its anti-inflammatory activity.

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