The clinical features and results of treatment were reviewed in 17 traumatic palsies of the posterior interosseous nerve. Variations in clinical features depended on whether the recurrent branch or descending branch of the posterior interosseous nerve was injured. Seven patients had nerve repair, and two were treated by tendon transfers. Eight patients were treated conservatively. Sixteen of 17 patients recovered to more than M4 motor power at final follow-up. Associated muscle damage worsened the functional result.

Abstract:We have developed a one-pot ring-closing metathesis (RCM)/oxidation methodology to yield various 2-quinolines from 2-vinyl-N-allylaniline derivatives. This is a first example of an oxidation involving methylene (CH 2 ) groups with modified Grubbs-type ruthenium complexes. Hence, this adds an example of a non-methathesis reaction using a ruthenium carbene catalyst.

This study was designed to examine the effect of aging on bone formation induced by recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with a fibrous collagen membrane (FCM). Implantation was done subperiosteally in bilateral palatal grooves in 34 male Wistar rats divided into three age groups: a 10-week-old group (10w group), a 30-week-old group (30w group) and a 70-week-old group (70w group). RhBMP-2-combined FCMs were implanted on the left palatal grooves as BMP-implanted sites (BMP site), while rhBMP-2 was not implanted on the right palatal grooves as control sites. The rats were sacrificed 6 weeks after implantation, and histometric evaluations were performed. New bone formation was observed in every site of each age group and the new bone was almost completely continuous with the original bone. The new bone volume (NBV) of the BMP site was significantly higher than that of the control site in each age group. The NBV of both the control and BMP sites were highest in the 10w group and lowest in the 70w group. The disparity of NBV between the control and BMP sites, which indicated the response to implanted BMP excluding the effect of skeletal growth and surgical stimulation, did not significantly differ among the age groups. These results indicate that rhBMP-2-combined FCM has the ability to induce new bone formation continuous with original bone even in senescent rats. Furthermore, it appeared that, in the case of palatal subperiosteal implantation, the responsiveness to implanted BMP was independent of age, although the total volume of newly formed bone declined with aging.

Structure. -This reaction yields chromophoric isoindolo[2,1-α]quinoline derivatives with the color depending on the substituents. -(ARISAWA*, M.; FUJII, Y.; KATO, H.; FUKUDA, H.; MATSUMOTO, T.; ITO, M.; ABE, H.; ITO, Y.; SHUTO, S.; Angew. Chem., Int. Ed. 52 (2013) 3, 1003-1007, http://dx.doi.org/10.1002/anie.201206765 ; Fac. Pharm. Sci., Hokkaido Univ., Sapporo 060, Japan; Eng.) -Roessler 22-172

Assisted tandem catalytic reactions are defined as catalyzed reaction sequences that proceed through more than one mechanism, but with just one precatalyst. [1] In these reactions, the catalyst of the first cycle is transformed into the catalyst of the second cycle by a chemical initiator, for example, an additive that induces an organometallic transformation in situ. Over the past decade, several reaction sequences comprising an olefin-metathesis step and a subsequent nonmetathesis [2] transformation of the newly generated carbon= carbon bond were developed. For example, olefin metathesis can be combined with hydrogenation [3] or isomerization [4] by in situ conversion of a Ru-carbene into a Ru-hydride. [5] Ruthenium-alkylidene-catalyzed tandem transformations that were developed to date include olefin metathesis, followed by cyclopropanation, [6] hydrovinylation, [7] hydroarylation, [8] the aza-Michael reaction, [9] the hetero-Pauson-Khand reaction, [10] or oxidation. [11] On the other hand, [RuClCp*] and the "first generation" Grubbs metathesis complex A (Figure 1) catalyze an azidealkyne cycloaddition reaction to give 1,5-substituted triazoles, [12] and an intramolecular [3+2] cycloaddition of alk-5ynylidenecyclopropanes to give bicyclo[3.3.0]octane, [13] respectively.In our search for novel and efficient Ru-catalyzed reactions, [2c, 3, 11d, 14] we developed a one-pot ring-closing metathesis/oxidation methodology to produce various 2-quinolones from N-allyl-2-vinylaniline derivatives (Scheme 1). [11d] Oxidation of the a-methylene group of amines to the corresponding amides is very difficult. [15] The key intermedi-