Background: Currently, there is no method of accurately diagnosing bacterial translocation (BT) in humans. BT may be related to changes in intestinal permeability. In this study, we examined the correlation between intestinal permeability using polyethylene glycol (PEG) 4000 and BT. Materials and Methods: Under general anesthesia, laparotomy was done in rats, and PEG4000 was administered to the small intestine. We prepared models of invasive stimulation in which lipopolysaccharide (LPS) was intravenously administered, and a hemorrhagic shock model in which blood pressure was decreased to 30 mm Hg. Blood PEG4000 levels were measured. We also measured blood PEG levels in a model in which oxygen was administered to treat hemorrhagic shock. In all models, the presence or absence of BT development was evaluated. Results: In groups given LPS, mean blood PEG levels were significant higher than in the group treated with saline solution. In the hemorrhagic shock group, the mean PEG level was increased but was slightly inhibited by oxygen administration. In the LPS and hemorrhagic shock groups, the incidene of BT was significantly greater than in the control group. In the hemorrhagic shock group, the incidence of BT was 0% after oxygen administration. There was a correlation between the incidence of BT and changes in the intestinal permeability of PEG4000 (R² = 0.824). Conclusions: LPS stimulation enhanced intestinal permeability in a dose-dependent manner. An increase in intestinal permeability was correlated with the incidence of BT. Blood PEG4000 levels correlated positively with the grade of invasion and the incidence of BT.

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A case of multiple lymphangioma of the colon, a very rare disease, is reported. A 62-year-old woman consulted her home doctor with complaints of recurrent diarrhea and tenesmus, and multiple polypoid lesions were found in the ascending to transverse colon after barium enema. A colonofiberscope revealed a smooth surfaced and pale-blue soft submucosal tumor, which was revealed by colonofiberscopic ultrasonography as a cystic lesion having some septums. The Diagnosis of a lymphatic cyst of the colon was made and a right hemicolectomy was performed.Histologically, any tumor was diagnosed as cystic lymphangioma. Agha reported 22 cases of colonic lymphangioma abroad and this is the 50th case reported in Japan. According to the Japanese literature, the average age of the patients is 53.1 yr and this disease is found more often in males than females with a ratio of 3 to 2. The lesion is present more often in the right-sided colon. It is said that the differential diagnosis of colonic submucosal tumor is difficult. But the ultrasonic colonofiberscope is an efficient apparatus with which one can determine the location and characteristics of the lesion, and it is possible that it will be an useful means of differential diagnosis.

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