A 49-year-old woman with immunoglobulin GK multiple myeloma developed progressive visual loss with bilateral upper and lower central arcuate scotomas. Funduscopic and electrophysiologic studies indicated bilateral optic neuropathy. The immunoglobulin G fraction of the patient's serum reacted with retinal ganglionic cells in bovine retina. The visual abnormalities remitted after myeloablative chemotherapy and disappearance of the paraprotein.

The clinical, h::ematological and pathological features of a case of histiocytic medullary reticulosis are described. The course of the illness was punctuated by a number of exacerbations characterized by a sudden onset of fever. The h::ematological features were unusual, in that an::emia, which is usually a severe and very prominent feature of the disease, was only mild and intermittent. The diagnosis was not suspected clinically and was finally made by histological examination of splenic tissue obtained at splenectomy. The course of the disease was unaffected by splenectomy and by treatment with cyclophosphamide.Brief reference is made to the relevant literature, and the features of interest are discussed.

The clinical and h

No abstract

No abstract