[reaction: see text] Palladium acetate was supported on amorphous silica with the aid of an ionic liquid, [bmim]PF(6). The immobilized catalyst was highly efficient in promoting the Mizoroki-Heck reaction without a ligand in n-dodecane for at least six reuses, in 89 approximately 98% yields. The TON and TOF reached 68 400 and 8000, respectively.
The naturally occurring guaianolides, namely mokko lactone (1), dehydrocostus lactone (2), eremanthin (3), and related guaianolides, 16, 17, 21, 22, 28-31, 33, 36, 37, and 39, have been synthesized starting from l-alpha-santonin in an effort to examine their structure-activity relationship as inhibitors of the killing function of cytotoxic T lymphocytes (CTL) and the induction of intercellular adhesion molecule-1 (ICAM-1). It was observed during the present study that the guaianolides possessing an alpha-methylene gamma-lactone moiety, i.e., 2, 3, 30, 33, 37, and 39, exhibited significant inhibitory activity toward the killing function of CTL and the induction of ICAM-1.
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