This paper is a comprehensive review of biofouling in reverse osmosis modules where we have discussed the mechanism of biofouling. Water crisis is an issue of pandemic concern because of the steady rise in demand of drinking water. Overcoming biofouling is vital since we need to optimize expenses and quality of potable water production. Various kinds of microorganisms responsible for biofouling have been identified to develop better understanding of their attacking behavior enabling us to encounter the problem. Both primitive and advanced detection techniques have been studied for the monitoring of biofilm development on reverse osmosis membranes. Biofouling has a negative impact on membrane life as well as permeate flux and quality. Thus, a mathematical model has been presented for the calculation of normalized permeate flux for evaluating the extent of biofouling. It is concluded that biofouling can be controlled by the application of several physical and chemical remediation techniques.

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