In the present study, pharmacological activities antipyretic and CNS depressant activity of crude extract of isolated from Western Ghats soil of Agumbe, Karnataka, India have been studied. T isolate PO-178 was grown in starch casein nitrate broth medium. The culture filtrate was condensed to obtain crude extract. Anti-inflammatory, analgesic, antipyretic and CNS depressant activities of the crude extract were determined by Carrageenan edema, tail flick, yeast induced pyrexia and s The extract exhibited dose dependent anti depressant activity, however, the activities observed were lesser than st Further studies are under progress to recover pharmacologically active principles from the extract of Streptomyces species PO-178 and to determine their activities.

Article Information The present study was carried out to investigate the analgesic activity of leaf extract of Olea dioica (Roxb) belonging to the family Oleaceae. Acute toxicity was determined by administering single oral dose of 2000mg/kg b.w to Swiss albino mice. The results showed no toxicity in terms of general behavior change and mortality and LD50 was found to be more than 2,000 mg/kg. Analgesic effect of extract was evaluated in Swiss Albino mice by Tail flick method. The animals were administered with 100, 200 and 300 mg extract/kg b.w and the positive control used for the study was Pentazocine (5mg/kg). The extract and Pentazocine showed significant analgesic activity as compared to control. The extract increased pain threshold indicating that the extract exhibit analgesic activity.