With the exponential improvement of software technology during the past decade, many efforts have been made to design remote and personalized healthcare applications. Many of these applications are built on mobile devices connected to the cloud. Although appealing, however, prototyping and validating the feasibility of an application-level idea is yet challenging without a solid understanding of the cloud, mobile, and the interconnectivity infrastructure. In this paper, we provide a solution to this by proposing a framework called HealthNode, which is a general-purpose framework for developing healthcare applications on cloud platforms using Node.js. To fully exploit the potential of Node.js when developing cloud applications, we focus on the fact that the implementation process should be eased. HealthNode presents an explicit guideline while supporting necessary features to achieve quick and expandable cloud-based healthcare applications. A case study applying HealthNode to various real-world health applications suggests that HealthNode can express architectural structure effectively within an implementation and that the proposed platform can support system understanding and software evolution.