BACKGROUND:The most reliable prognostic factor in colon cancer is the TNM classification. The objective of this study was to assess and compare the prognostic role of tumor-infiltrating lymphocytes (TILs) in stage II colon cancer. METHODS: Immunohistochemistry was used to assess the density of TILs that were positive for cluster of differentiation 3 (CD3) (T-cell coreceptor), CD45 isoform RO (CD45RO) (protein tyrosine phosphatase), nuclear transcription factor forkhead box P3 (FOXP3), and CD25 (a type I transmembrane protein) according to tumor site (intraepithelial and stromal) in samples from 87 patients who had stage II colon cancer. These variables were evaluated for their association with histopathologic features along with overall survival (OS) and disease-free survival (DFS). RESULTS: Intraepithelial CD3-posititve (CD3þ), CD45ROþ, CD25þ, and FOXP3þ TILs were associated significantly with better DFS (P ¼ .049, P ¼ .009, P ¼ .013, and P ¼ .001, respectively). The estimated 5-year OS rates for patients who had high-density CD45ROþ and FOXP3þ expression was 100% for both compared with 79.2% and 78.8% for patients who had low-density CD45ROþ and FOXP3þ expression (P ¼ .017 and P ¼ .040, respectively). A significant prognostic factor for both OS and DFS was high-density stromal CD45ROþ lymphocytic infiltration (OS: P ¼ .031; relative risk [RR], 0.134; 95% confidence interval [CI], 0.015-1.164; DFS: P ¼ .013; RR, 0.198; 95% CI, 0.055-0.710); whereas intraepithelial FOXP3þ expression was an independent prognostic factor for DFS (P ¼ .032; RR, 0.108; 95% CI, 0.014-0.821). CONCLUSIONS: FOXP3þ and CD45ROþ TILs demonstrated independent prognostic significance for survival in the current investigation. These results may help to improve the prognostication of early stage colon cancer. Cancer 2010;116:5188-99.

Flexible stents effectively relieved acute colonic obstruction secondary to malignant rectosigmoid neoplasm. Stent placement allowed patients to undergo single-stage surgery in most cases and provided palliative decompression in cases of inoperable or disseminated disease.

In this large cross-sectional study, higher levels of serum triglycerides were significantly associated with an increasing prevalence of both non-advanced and advanced colorectal adenomas, while higher levels of ApoA-1 and HDL cholesterol were significantly associated with an increasing prevalence of non-advanced adenomas.