AIM:To investigate the effect of Scutellariae Radix extract (SRE) on ulcerative colitis (UC) in rats induced by dextran-sulfate sodium (DSS). METHODS:Colitis was induced in male Sprague-Dawley (SD) rats (170-180 g) by 4% dextran sulfate sodium (DSS, wt/v; MW 54 000) in drinking water for 8 d. The treated rats received 4% DSS and SRE orally (100 mg/kg per day). Control rats received either tap water or SRE only. Macroscopic assessment which included body weight changes, fecal occult blood and stool consistency were determined daily. At the appointed time, the rats were sacrificed and the entire colons were removed. The colon length and the myeloperoxidase (MPO) activity were measured. The severity of colitis was graded by morphological and histological assessments. The ion transport activity of the colonic mucosa was assessed by electrophysiological technique. RESULTS:Rats treated with oral administration of 4% DSS regularly developed clinical and macroscopic signs of colitis. Treatment with SRE relieved the symptoms, including the reduction in body weight, shortening and ulceration of the colon. Administration of SRE also significantly reduced the histological damage induced by DSS. Moreover, the ISC responses of the colonic mucosa to forskolin were suppressed after the induction of colitis. The stimulated ion transport activity of DSS-rats treated with SRE displayed significant improvement in the secretory responsiveness.

In this paper, we investigate the following two limitations for the existing distractor generation (DG) methods. First, the quality of the existing DG methods are still far from practical use. There are still room for DG quality improvement. Second, the existing DG designs are mainly for single distractor generation. However, for practical MCQ preparation, multiple distractors are desired. Aiming at these goals, in this paper, we present a new distractor generation scheme with multi-tasking and negative answer training strategies for effectively generating multiple distractors. The experimental results show that (1) our model advances the state-of-the-art result from 28.65 to 39.81 (BLEU 1 score) and (2) the generated multiple distractors are diverse and shows strong distracting power for multiple choice question.

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The secretion of Cl− across distal colonic crypt cells provides the driving force for the movement of fluid into the luminal space. 17β-Estradiol (E2) produces a rapid and sustained reduction in secretion in females, which is dependent on the novel protein kinase Cδ (PKCδ) isozyme and PKA isoform I targeting of KCNQ1 channels. This sexual dimorphism in the E2 response is associated with a higher expression level of PKCδ in female compared with the male tissue. The present study revealed the antisecretory response is regulated throughout the female reproductive (estrous) cycle and is primed by genomic regulation of the kinases. E2 (1-10 nm) decreased cAMP-dependent secretion in colonic epithelia during the estrous, metestrous, and diestrous stages. A weak inhibition of secretion was demonstrated in the proestrous stage. The expression levels of PKCδ and PKA fluctuated throughout the estrous cycle and correlated with the potency of the antisecretory effect of E2. The expression of PKCδ and PKA were up-regulated by estrogen at a transcriptional level via a PKCδ-MAPK-cAMP response element-binding protein-regulated pathway indicating a genomic priming of the antisecretory response. PKCδ was activated by the membrane-impermeant E2-BSA, and this response was inhibited by the estrogen receptor antagonist ICI 182,780. The 66-kDa estrogen receptor-α isoform was present at the plasma membrane of female colonic crypt cells with a lower abundance found in male colonic crypts. The study demonstrates estrogen regulation of intestinal secretion both at a rapid and transcriptional level, demonstrating an interdependent relationship between both nongenomic and genomic hormone responses.

In this paper, we investigate the following two limitations for the existing distractor generation (DG) methods. First, the quality of the existing DG methods are still far from practical use. There are still room for DG quality improvement. Second, the existing DG designs are mainly for single distractor generation. However, for practical MCQ preparation, multiple distractors are desired. Aiming at these goals, in this paper, we present a new distractor generation scheme with multi-tasking and negative answer training strategies for effectively generating multiple distractors. The experimental results show that (1) our model advances the state-of-the-art result from 28.65 to 39.81 (BLEU 1 score) and (2) the generated multiple distractors are diverse and shows strong distracting power for multiple choice question.