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Background and aim:Polymethyl methacrylate (PMMA) is broadly used as a removable prosthesis denture base. Silver Nano-particles (AgNPs) had been included to PMMA because of their antibacterial homes and higher thermal conductivity, at the same time as it had a destructive effect on the flexural strength and coloration stability that is probably resulted from the inhomogeneous combination. The motive of this research changed into to discover whether the addition of (AgNPs) to PMMA either in liquid form or in powder nation can enhance the flexural strength and the shade balance of PMMA. Also evaluating an edentulous menopausal lady as a multidisciplinary control after wearing a denture made from silver nanoparticles added to (PMMA) denture base. Materials and methods:Fifty specimens of heat cure acrylic resin had been organized for flexural strength and color stability. Twenty-five for each test that become divided into 3 groups. Group 1 was the control group (unmodified acrylic resin specimens) and group 2 turned into Nano silver introduced within the form of powder to the polymer of (PMMA), while group 3 was Nano silver brought in the form of liquid to the monomer of (PMMA). Group 2 and 3 specimens had been break up into subgroups A and B 5 each, with 0.2%, and 0.4 % wt. of Nano silver addition to (PMMA) respectively. A flexural strength was measured via the usage of an Instron regular testing machine. A double beam ultra-violet visible spectrophotometer was checked to the degree of coloration stability. One edentulous menopausal woman that present process treatment below a gynecologist for menopausal signs and symptoms was selected as a case report and received denture made out of silver nanoparticles added to acrylic resin and patient satisfaction became evaluated after 4 months. The results have been gathered tabulated and statically analyzed.Results: There has been a massive distinction in the flexural power values among all corporations (p< 0.05) relative to the non-changed heat treatment (control group). Acrylic resin samples with 0.2% in liquid additive form (3A) ended in more flexural power then 0.4% addition (3B) in comparison to different changed groups .The samples with 0.4 % in powder form(2B) had a lowest (1514) Hoda A Rashad and Faten A S Abutaleb E.D.J. Vol. 64,No. 2 flexural strength in comparison to the all groups (p< 0.05). In comparing the color variations (ΔE) comparable to control group, group 3A and group 3B, showed lowest color variations respectively. At the same time group 2Aand 2B ended in highest shade distinction .Conclusion: Set up on the effects of this results, modifying PMMA with Nano silver debris led to lower in flexural strength and shade stability, addition of Nano silver particles in liquid shape was higher than powder form as concerning flexural strength and better color difference and the addition percentage of 0.2 became better than 0.4. Menopausal pride turned into higher and her complain became managed with the new denture.