Abstract:The present study aimed to investigate the effect of short-term solution focused therapy on distress tolerance and social adjustment of patients with MS (Multiple Sclerosis) in Sari. The sample of this study consisted of all MS patients in Sari who were members of MS society of Mazandaran province including 480 patients. Accordingly, two groups of 13 subjects, each including 10 women and 3 men, were randomly assigned into experimental group and control group. Using pretest and posttest, the effect of short-term solution focused therapy on the experimental group was investigated. For data collection, Distress Tolerance Scale (DTS) and Social Adjustment Scale (SAS) were used. Data were processed using analysis of covariance and the results confirmed research hypotheses. This means that short-term solution focused therapy increased distress tolerance and social adjustment of patients with MS.