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In aquaculture, the wide use of high-fat diet (HFD) could save protein and reduce feed costs, but also cause lipid deposition and impair flesh quality in fish. We hypothesized that tea polyphenols (TP) could alleviate the adverse effects of HFD on flesh quality in fish; thus, in the present study, GIFT tilapias were fed with control diet (60 g/kg fat), HFD (120 g/kg fat) and the HFD supplemented with two doses of TP (50 and 200 mg/kg, respectively) for 8 weeks. As compared with the control,