The influence of the nursing safety management in nursing quality of hemodialysis room was deeply analyzed through the evaluation index study of nursing quality in hemodialysis room. Sixty-two patients were selected from hemodialysis rooms as study samples, and 31 patients who had not carried out nursing safety management from September 2018 to September 2019 were selected as control samples. Thirty-one patients who underwent nursing safety management from September 2019 to September 2020 were included in the observation group. By comparing the samples of the control group and the observation group, it was found that the comprehensive score of adverse reaction risk nursing quality and nursing satisfaction score between the groups were significantly improved; P < 0.05. Nursing safety management can effectively reduce the quality of nursing in hemodialysis room and greatly reduce the occurrence of adverse risks.