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A new efficient method was developed for the preparation of 2-methyl-1-(2-morpholinoethyl)-1H-indole-3-carboxylic acid. The new method involves N-alkylation of 7-methoxy-2-methylindole with 4-(2-chloroethyl)morpholine hydrochloride followed by trichloroacetylation and hydrolysis in 3 steps and 88% overall yield.

151ChemInform Abstract Dithiaalkanedioic acids such as (IV), (V) and (VII) are prepared, starting with the alkynes (I) and the aromatic aldehydes (VI) respectively. These products are investigated as leucotriene antagonists. (IR-, 1H-NMR-data).