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Although flap salvage should be attempted, multiple attempts are not recommended, especially for muscle-only flaps. Combined arteriovenous and late thrombosis has a dismal prognosis regardless of different salvage techniques. © 2015 Wiley Periodicals, Inc. Head Neck 38: E771-E775, 2016.

Background: The chromatin regulator BRPF1 recognizes different epigenetic marks and activates multiple histone acetyltransferases, but little is known about its biological functions in mammals. Results: Forebrain-specific inactivation of the mouse gene causes neocortical abnormalities and partial agenesis of the corpus callosum. Conclusion: Mammalian BRPF1 is important for forebrain development. Significance: This study links a unique chromatin regulator to mammalian brain development.