Bidirectional maximum matching algorithm (BMM) combined positive maximal matching and reverse maximal matching algorithm, it was a more commonly used word segmentation method now, but it was low efficient and couldn’t solve the ambiguity. Therefore, an improved method was proposed combining with improved dictionary structure, and changing maximal matching word length dynamically to improve the efficiency of word segmentation. In order to get the correct segmentation results, we also proposed several rules. Compared with traditional segmentation methods, it proves that bidirectional maximal matching word segmentation with rules has higher speed and precision.

e16616 Background: RC48 is a novel antibody drug conjugate that targets the Her2 protein and has shown promising efficacy in advanced urothelial cancer. However, its efficacy and safety in early-stage urothelial carcinoma are yet to be fully explored. To address this, we retrospectively collected the clinical data of patients with high-risk non-muscle-invasive bladder cancer (HR-NMIBC) who received rc48. Methods: In this retrospective study, 19 patients with Her2-overexpressing (IHC 2+ or 3+) HR-NMIBC who were unable to undergo complete tumor resection or tolerate surgery were included， and clinical data were retrospectively collected. Pathological complete response (CR), partial response (PR), stable disease (SD), objective response rate (ORR), duration of response (DOR), cystectomy-free survival (CFS), and event-free survival (EFS) were used for data analysis. Results: We collected clinical data from a total of 19 patients. The median age of patients was 69 years (range: 58 to 81). Seven patients (36.8%) received RC48 monotherapy, while 12 patients (63.2%) received RC48 combined with tislelizumab. A CR was achieved in 14 patients (73.7%, 95% CI: 48.6% to 89.9%), with a partial response (PR) in 1 patient (5.3%, 95% CI: 0.3% to 8.1%) and stable disease (SD) in 4 patients (21.1%, 95% CI: 7.0% to 46.1%). The overall ORR was 78.9% (95% CI: 53.9%, 93.0%). In 14 pts (73.7%) with Her2 IHC 3+, 12 achieved ORR, with an ORR of 85.7% (95% CI: 56.2%, 97.5%). Among the 5 pts with Her2 IHC 2+, 3 achieved ORR, with an ORR of 60.0% (95% CI: 17.0%, 92.7%). In addition, among the 5 pts who had prior PD-1 treatment failure, ORR was 60.0% (95% CI: 17.0%, 92.7%), and 2 achieved CR (40.0%, 95% CI: 7.3%, 83.0%). 1 patient died due to non-treatment-related causes. The duration of response (DOR) rate was 92.9% (95% CI: 80.3%, 100.0%), and the twelve-month DOR rate was 61.9% (95% CI: 27.4%, 100.0%). The twelve-month cystectomy-free survival (CFS) rate was 84.2% (95% CI: 69.3%, 100.0%), and the median CFS was not achieved. The twelve-month EFS rate was 75.8% (95% CI: 48.3%, 100.0%), and the median EFS was not achieved. The most commonly occurring grade 1-2 treatment-related adverse events (TRAEs) were alopecia (36.8%), rash (36.8%), pruritus (36.8%), anorexia (31.6%), and fatigue (26.3%). Grade 3-4 TRAEs were reported in 3 patients (6.3%), including rash, pruritus, leukopenia, and neutropenia. No grade 5 adverse events were reported. Conclusions: The results of this retrospective study show that both RC48 monotherapy and RC48 combined with tislelizumab have promising efficacy in the treatment of NMIBC. The overall response rate was high, with tolerable and manageable treatment-related adverse events. These findings suggest that RC48 monotherapy and RC48 combined with tislelizumab may be successful strategies for the treatment of NMIBC. Now, we are conducting a prospective study to further clarify the value of RC48 combining tislelizumab in NMIBC.

In this paper, we introduced one kind of special compound noun in Chinese patent texts composed of verb and noun, and presented a rule-based method for Chinese-English patent Machine Translation (MT) to improve the identification of compound nouns, with the purpose of decreasing the possibilities that verbs may disturb the identification of core predicate verb. The system first tagged different weights on verbs then determined the properties of verbs and recognized the compounds according to the weights. We then conducted experiments with the method, which proved that the method could identify compound nouns efficiently.

Low similarity and unreasonable design now appeared in distracters generation of English words in the process of learning English words. This paper proposed a new algorithm to solve this problem by researching Edit Distance and LCS algorithm. Comparing with traditional algorithms, the accuracy of similarity has been improved in this algorithm. Finally, combined with words’ part of speech, we generated more reasonable distracters in the experiments.

For the requirement of the department for aviation accident investigation, a computer information system of processing the broken tape of flight data recorder has been designed. The main principles of the system are that magnetic track images are first preprocessed using image processing techniques, furthermore, the position coordinates of tracks are obtained using image recognizing techniques, finally, the data corresponding to track coordinates are obtained by encoding the track coordinates using the serial-parallel scanning method that is specially designed. The accurate ratio of automatic encoding is 99.3%. The times of automatic encoding are reduced to proximate 5 seconds from about 4 hours of two operators for one frame track image. This system is significant for aviation accident investigations.