Personalized dialogue systems explore the problem of generating responses that are consistent with the user's personality, which has raised much attention in recent years. Existing personalized dialogue systems have tried to extract user profiles from dialogue history to guide personalized response generation. Since the dialogue history is usually long and noisy, most existing methods truncate the dialogue history to model the user's personality. Such methods can generate some personalized responses, but a large part of dialogue history is wasted, leading to sub-optimal performance of personalized response generation. In this work, we propose to refine the user dialogue history on a large scale, based on which we can handle more dialogue history and obtain more abundant and accurate persona information. Specifically, we design an MSP model which consists of three personal information refiners and a personalized response generator. With these multi-level refiners, we can sparsely extract the most valuable information (tokens) from the dialogue history and leverage other similar users' data to enhance personalization. Experimental results on two real-world datasets demonstrate the superiority of our model in generating more informative and personalized responses.

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Alzheimer disease (AD) is mainly manifested as insidious onset, chronic progressive cognitive decline and non-cognitive neuropsychiatric symptoms, which seriously affects the quality of life of the elderly and causes a very large burden on society and families. This paper uses graph theory to analyze the constructed brain network, and extracts the node degree, node efficiency, and node betweenness centrality parameters of the two modal brain networks. The T test method is used to analyze the difference of graph theory parameters between normal people and AD patients, and brain regions with significant differences in graph theory parameters are selected as brain network features. By analyzing the calculation principles of the conventional convolutional layer and the depth separable convolution unit, the computational complexity of them is compared. The depth separable convolution unit decomposes the traditional convolution process into spatial convolution for feature extraction and point convolution for feature combination, which greatly reduces the number of multiplication and addition operations in the convolution process, while still being able to obtain comparisons. Aiming at the special convolution structure of the depth separable convolution unit, this paper proposes a channel pruning method based on the convolution structure and explains its pruning process. Multimodal neuroimaging can provide complete information for the quantification of Alzheimer’s disease. This paper proposes a cascaded three-dimensional neural network framework based on single-modal and multi-modal images, using MRI and PET images to distinguish AD and MCI from normal samples. Multiple three-dimensional CNN networks are used to extract recognizable information in local image blocks. The high-level two-dimensional CNN network fuses multi-modal features and selects the features of discriminative regions to perform quantitative predictions on samples. The algorithm proposed in this paper can automatically extract and fuse the features of multi-modality and multi-regions layer by layer, and the visual analysis results show that the abnormally changed regions affected by Alzheimer’s disease provide important information for clinical quantification.