Phthalate (PAEs) is an environmental pollutant and can enter the human body through respiratory tract inhalation, skin contact, and food intake. As one of the food plasticizers, PAEs are seriously harming human health. They migrate into the food and enter the human body through the food packaging materials to affect the normal physiological metabolism of the human body. In this paper, we mainly describe how PAEs can induce obesity by interacting with nuclear receptors, inhibiting the expression of genetic epigenetic factor sirtuin, increasing the content of Bifidobacteria in the intestinal tract, and reducing the secretion of thyroid hormones (TH).Then, two feasible solutions were introduced. One was to control obesity by inhibiting peroxisome proliferator-activated receptor gamma (PPARγ) through celery oil seeds, and the other was to control obesity by supplementing Bifidobacterium longum APC1472 to improve intestinal microorganism. In conclusion, this article summarizes the latest progress in the mechanism of PAEs exposure to obesity.