Neuraminidase (NA) is one of the most important targets to screen the drugs of anti-influenza virus A and B. After virtual screening approaches were applied to a compound database which possesses more than 10000 compound structures, 160 compounds were selected for bioactivity assay, then a High Throughput Screening (HTS) model established for influenza virus NA inhibitors was applied to detect these compounds. Finally, three compounds among them displayed higher inhibitory activities, the range of their IC50 was from 0.1 micromol/L to 3 micromol/L. Their structural scaffolds are novel and different from those of NA inhibitors approved for influenza treatment, and will be useful for the design and research of new NA inhibitors. The result indicated that the combination of virtual screening with HTS was very significant to drug screening and drug discovery.

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This paper documents the development of a high performance head mounted 3D displays using Micro‐OLEDs. The optical system couples commercial full resolution 1920*1080 pixel 0.71inch OLED microdisplay, having a diagonal field of view (FOV) of 53 degree and exit pupil diameter over 7mm and eye relief larger than 14 mm And the image distortion is less than 1.5%. An MTF of over 0.6 was achieved at 30lp/mm, ensuring a high image viewing quality of the display. The optical engine implements the diopter adjustment function, supporting diopter correction from +3D to ‐8D without degrading image quality. A driving solution based on FPGA is developed to support various high definition 3D formats.