To probe CP violation in the leptonic sector using GeV energy neutrino beams in current and future experiments using argon detectors, precise models of the complex underlying neutrino and antineutrino interactions are needed. The E12-14-012 experiment at Jefferson Lab Hall A was designed to perform a combined analysis of inclusive and exclusive electron scatterings on both argon (N = 22) and titanium (Z = 22) nuclei using GeV-energy electron beams. The measurement on titanium nucleus provides essential information to understand the neutrino scattering on argon, large contribution to which comes from scattering off neutrons. Here we report the first experimental study of electron-titanium scattering as double-differential cross section at beam energy E = 2.222 GeV and electron-scattering angle θ = 15.541• , measured over a broad range of energy transfer, spanning the kinematical regions in which quasielastic scattering and delta production are the dominant reaction mechanisms. The data provide valuable new information needed to develop accurate theoretical models of the electromagnetic and weak cross sections of these complex nuclei in the kinematic regime of interest to neutrino experiments. (6) 014617-1

Covalent organic frameworks (COFs), as one of the most significant members of the porous organic frameworks, have been well used in the photocatalysis owing to their outspread π-conjugated framework, high crystallinity and regular pore structure. Herein, after reducing the labile imine-linked COF-300 to the more stable aminelinked COF-300-AR, we for the first time demonstrated that COF-300-AR was the light-responsive oxidase mimic. COF-300-AR exhibited excellent oxidase-mimicking activity under purple light stimulation (λ = 400 nm), which can catalyze the oxidation of classical substrates such as 3,3′,5,5′-tetramethylbenzydine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) by the formation of • OH and O 2•− free radicals in the presence of dissolved oxygen. The COF-300-AR oxidase mimic has outstanding advantages of easy light control, high stability, good reusability, and highly catalytic oxidation capacity and has been applied to detect glutathione (GSH) levels in HL60 cells with good selectivity and high sensitivity. This study will broaden the sensing applications of COFs and offer a promising build block for the construction of artificial enzymes.

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The success of the ambitious programs of both long-and short-baseline neutrino-oscillation experiments employing liquid-argon time-projection chambers will greatly rely on the precision with which the weak response of the argon nucleus can be estimated. In the E12-14-012 experiment at Jefferson Lab Hall A, we studied the properties of the argon nucleus by scattering a high-quality electron beam off a high-pressure gaseous argon target. Here, we present the measured 40 Ar(e, e ) double differential cross section at incident electron energy E = 2.222 GeV and scattering angle θ = 15.54 • . The data cover a broad range of energy transfers, where quasielastic scattering and delta production are the dominant reaction mechanisms. The result for argon is compared to our previously reported cross sections for titanium and carbon, obtained in the same kinematical setup.Precise determination of charge-parity (CP) symmetry violation in the lepton sector-necessary to shed light on the matter-antimatter asymmetry in the universeis among the highest priorities of particle physics. Over the next two decades, this issue will be a primary science goal of the Deep Underground Neutrino Experiment (DUNE) [1], together with a search for proton decay, measurement of the electron-neutrino flux from a corecollapse supernova-should one occur in our galaxy during the lifetime of DUNE-and search for physics beyond the standard model.In the next few years, the Short-Baseline Neutrino (SBN) program [2] at Fermilab will provide a definitive answer to the question of the existence of sterile neutrinos, which could be the source of electron-like events recently reported with statistical significance 4.8σ by the MiniBooNE Collaboration [3].Both DUNE and the SBN program (will) employ liquid-argon time-projection chambers as their detectors, the advantages of which are low threshold momenta for particle detection and high spatial resolution, allowing (among others) for precise neutrino-energy reconstruction and distinguishing photons from electrons. As a consequence, the success of both programs in studying neutrino oscillations with unprecedented precision will greatly rely on the precision with which we understand