The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.

No abstract

A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.

Mecamylamine, 3-methylaminoisocamphane hydrochloride, a secondary amine with a pka of 11.4, can be both actively secreted and actively reabsorbed by the renal tubules in the dog. Net secretion occurs when the urine is acid; net reabsorption occurs when the urine is alkaline. A direct renal extraction study showed that tubular secretion occurred at rates equal to effective renal plasma flow. No self-depression of tubular secretion was observed at increased loads. The clearance of mecamylamine was depressed below glomerular filtration rate when the urine became alkaline, whether or not a systemic alkalosis existed. In some experiments, the clearance was as low as 3 ml/min., corresponding to reabsorption of more than 90% of the filtered drug. The secretory mechanism is not identical with that for p-aminohippurate. Approximately one-fourth of an administered dose of mecamylamine is excreted in the urine within 24 hours, whether the drug is given orally or parenterally. These data are consistent with the biological evidence that absorption from the gastrointestinal tract is essentially complete, and that extrarenal factors are important in the over-all physiological economy of the drug.