The peripheral ossifying fibroma (POF) is a benign reactive gingival overgrowth; it occurs mainly in the anterior portion of maxilla in young adults, predominantly among females. The present report describes a case of POF in a male patient, which relapsed ten years later and of the lesion showed superficial bone erosion on surgical excision.

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INTRODUCTION: Primary Squamous Cell Carcinoma in the kidney is a rare malignant neoplasm associated with nephrolithiasis, typically monobacterial pyonephrosis and rarely Xanthogranulomatous pyelonephritis. It is an aggressive disease with a poor prognosis mostly due to lack of presenting clinical features like a palpable mass, gross haematuria and pain. We report a case presenting with renal calculus and pyonephrosis managed initially with percutaneous nephrostomy followed by nephrectomy due to complete loss of renal function. Histopathological evaluation revealed poorly differentiated squamous cell carcinoma which is managed by chemotherapy, although initially beneficial, patients later develop disseminated metastatic disease which holds a poor prognosis.

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