No abstract

All identified RHD variants contain at least one mutation that probably affects splicing to generate D-negative phenotype. Hence, ethnic RhD antigen background must be considered when developing transfusion and obstetric strategies.

Aims: Human platelet antigens (HPA) are involved in several clinical conditions, such as neonatal alloimmune thrombocytopenia (NAIt), platelet transfusion purpura (PtP), and refractoriness to platelet transfusion.the frequency of platelet antigens varies among populations. so far, typing of HPA systems has not been carried on Moroccan population. the frequencies of these antigens, their risk of alloimmunization, and their clinical implications and complications within Moroccan population are unknown. Our purpose is to define allele frequencies and genotypes in Moroccan population of the five HPA-1 to HPA-5 systems. Evaluate of the risk of anti-platelet alloimmunization among Moroccan blood donors, and estimate the mismatch probability of different platelet alloantigens, after

Aims: Determination of D variants is important for selection of blood products and to prevent anti-D-related hemolytic disease of the fetus and newborn. the prevalence of weak D phenotypes varies significantly among different ethnic populations. In Morocco, D variants have not been fully characterized. the purpose of this study was to determine prevalence of weak D among D negative and c/E+ blood donors and distribution of rhesus blood group antigens using serologic methods. Methods: A total of 15,865 blood samples from Moroccan blood donors were tested for D, c, c, E, e antigens by routine serologic methods. Among blood donors serologically D negative c+ and/or E+, 63 samples were tested for weak D by indirect antiglobuline test, enzymatic treated cells test and adsorption elution technique. results: Among 63 samples tested, 10 were positive by serologic methods

No abstract