In Ukraine, as in the rest of the world, the problem of the impact of occupational hazards and peculiarities of the labor process on higher nervous activity and general health of the working contingent remains relevant. The issue of fitness to work of employees, especially of dangerous, extreme professions is due to the extraordinary financial and economic, medical, social and psychological urgency of the problem. In the aspect of psychological and psychophysiological diagnosis, a large number of methodological approaches have been developed. Thorough psychophysiological diagnosis is the basis for predicting the effectiveness of employees and psychophysiological characteristics of the labor process. Thus, a wide variety of developed methodological approaches in modern conditions allows for effective psychophysiological examination of a particular field of activity of employees involved in high-risk work and opens further prospects for improving the psychophysiological support of professional activities of these persons. There is a need for theoretical substantiation and development of measures to improve the professional psychophysiological selection of industrial employees to perform high-risk work with further implementation and evaluation of medical, social and economic efficiency.