Purpose In Vitro Fertilization is an effective treatment for infertility; however, it has relatively low success in women of advanced maternal age (>37) who have a high risk of producing aneuploid embryos, resulting in implantation failure, a higher rate of miscarriage or birth of a child with chromosome abnormalities. The purpose of this study was to compare the implantation, miscarriage and live birth rates with and without preimplantation genetic screening (PGS) of embryos from patients aged 40 through 43 years. Methods This is a retrospective cohort study, comparing embryos screened for ploidy using trophectoderm biopsy and array comparative genomic hybridization to embryos that were not screened. We compared pregnancy outcomes for traditional fresh IVF cycles with day 5 embryo transfers, Frozen Embryo Transfer (FET) cycles without PGS and PGS-FET (FET of only euploid embryos) cycles of patients with maternal ages ranging from 40 to 43 years, undergoing oocyte retrievals during the period between 1/1/2011 and 12/ 31/2012. Results The implantation rate of euploid embryos transferred in FET cycles (50.9 %) was significantly greater than for unscreened embryos transferred in either fresh (23. Conclusions The present data provides evidence of the benefits of PGS with regard to improved implantation and live birth rate per embryo transferred.

STEET results in a high pregnancy rate, low multiple gestation rate and miscarriage rates. Despite the older age of STEET patients and transfer of twice as many embryos, the implantation rate for STEET was indistinguishable from that for egg donation. STEET offers an improvement to IVF, lowering risks without compromising pregnancy rate.

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Comparing the variables, the advanced paternal age was not related to an increase in the absolute number of embryo aneuploidy (p¼0.15). The sperm concentration showed no statistical difference between normo and oligospermic males (p¼0.70). According to strict morphology, Kruger < 4% had 36% of aneuploidy comparing with 42.5% in Kruger >¼ 4 (p¼ 0.38). Comparing sperm DNA fragmentation and aneuploidy, we did not observe difference between the groups using a cut-off of 15% in the fragmentation rate (p¼ 0.08).CONCLUSIONS: Therefore, these results suggested that the paternal factors, including age, sperm count, strict morphology and DNA sperm fragmentation were not related to the aneuploidy rate in preimplantation embryos in an oocyte donation program.

Lymphedema is defined as accumulation of fluid and fibroadipose tissues due to disruption of lymphatic flow. Our results demonstrate a significant difference of diffusion measures between lymphedema and normal groups. DKI and DTI derivatives have similar tendency when comparing lymphedema patients with healthy subjects. The diffusion properties may aid the diagnosis of lymphedema and have the potential for evaluating the severity in postoperative follow-up.