Skin is the external organ of human body that provides protection against environmental stress. Direct and indirect damage causes skin aging. Scientists have been struggling to explore the mechanisms of skin aging and to think of ways to delay this course. The role of mast cell in regulating skin aging has attracted much attention recently. The granules of mast cell contain a great diversity of highly toxic compounds and active mediators. Degranulation of mast cell in papillary dermis may lead to extra cellular matrix reconstruction, inflammation and angiogenesis which result in accelerated skin aging. Essential factors implicated in aging and tissue damage in skin are possibly related to mast cells. Mast cell is becoming an important target for anti-aging therapy. Many natural products capable of inhibiting mast cell activation are considered functional ingredients for anti-skin aging.