The ability to sense gravity is enhanced by an extracellular structure that overlies the macular sensory epithelium. This complex consists of high density particles, otoconia, embedded within a gelatinous membrane. The tilted mouse specifically lacks otoconia, yet has no other detectable anatomic lesions. Furthermore, the penetrance of the tilted phenotype is nearly 100%. This mouse provides a model to identify genes that are involved in the development and function of vestibular otoconia. Using SSLP markers, we have mapped the tilted (tlt) gene on mouse Chromosome (Chr) 5 between D5Mit421 and D5Mit353/D5Mit128/D5Mit266/D5Mit267 by analysis of the progeny of an intersubspecific F2 intercross. We also mapped the fibroblast growth factor receptor 3 (Fgfr3) gene, a potential candidate for tlt, and the Huntington's disease homolog (Hdh) gene to D5Mit268, approximately 4.3 centiMorgans (cM) from the tilted locus. This study excludes both Fgfr3 and Hdh as candidate genes for tlt and identifies closely linked microsatellite markers that will be useful for the positional cloning of tlt.

Commercial relational database systems today provide only limited temporal support. To address the needs of applications requiring rich temporal data and queries, we have built TIP (Temporal Information Processor), a temporal extension to the Informix database system based on its DataBlade technology. Our TIP DataBlade extends Informix with a rich set of datatypes and routines that facilitate temporal modeling and querying. TIP provides both C and Java libraries for client applications to access a TIPenabled database, and provides end-users with a GUI interface for querying and browsing temporal data.

Commercial relational database systems today provide only limited temporal support. To address the needs of applications requiring rich temporal data and queries, we have built TIP (Temporal Information Processor), a temporal extension to the Informix database system based on its DataBlade technology. Our TIP DataBlade extends Informix with a rich set of datatypes and routines that facilitate temporal modeling and querying. TIP provides both C and Java libraries for client applications to access a TIPenabled database, and provides end-users with a GUI interface for querying and browsing temporal data.