Purpose: To investigate the effect of Angong Niuhuang pill combined with mild therapeutic hypothermia on acute cerebral hemorrhage.Methods: From July 2017 to December 2020, 118 patients with acute cerebral hemorrhage treated in Dongying Honggang Hospital were recruited and assigned randomly to receive either routine treatment (control group, n = 59) or Angong Niuhuang Pill plus mild therapeutic hypothermia (study group, n = 59).Results: The study group showed a higher treatment efficacy (98.31 %) than the control group (82.78 %, p < 0.001). After treatment, patients in the study group achieved significantly higher Glasgow Coma Scale (GCS) scores (13.01 ± 2.31) and a lower intracranial pressure (14.25 ± 3.12) versus those in the control group (10.18 ± 2.05, 18.15 ± 3.05, respectively, p < 0.001). The study group displayed lower blood glucose and blood pressure levels than the control group (p < 0.001).Conclusion: Combined Angong Niuhuang Pill and mild therapeutic hypothermia therapy in patients with acute cerebral hemorrhage significantly improves treatment efficacy, as well as reduces intracranial pressure, blood sugar, blood pressure, and tumor marker levels in the patients. It also improves the ability of daily living of the patients and lowers the incidence of adverse reactions.