In this paper, we propose a dynamic audit service for verifying the integrity of an untrusted and outsourced storage. Our audit service is constructed based on the techniques, fragment structure, random sampling and index-hash table, supporting provable updates to outsourced data, and timely abnormal detection. In addition, we propose a probabilistic query and periodic verification for improving the performance of audit services. Our experimental results not only validate the effectiveness of our approaches, but also show our audit system verifies the integrity with lower computation overhead, requiring less extra storage for audit metadata.

Long noncoding RNA LINC00261 has been experimentally validated to function as a tumor suppressor in several cancers, but its pathological role and functional mechanism in non–small cell lung cancer (NSCLC) are largely unclear. In this study, LINC00261 was delineated in NSCLC to be significantly downregulated in cancer tissues compared with corresponding adjacent normal tissues. Low expression of LINC00261 predicted worse survival for patients with NSCLC. Overexpression of LINC00261 in NSCLC cell lines inhibited cell proliferation and invasion, meanwhile promoted apoptosis. Subcellular fractionation assay showed that LINC00261 existed mainly in the cytoplasm of NSCLC A549 cells and luciferase assay validated its direct interaction with miR‐522‐3p. Overexpression of miR‐522‐3p significantly ameliorated suppressive effects of LINC00261 on proliferation and invasion of NSCLC cells. Besides, miR‐522‐3p was found to be able to directly combine with the 3′‐untranslated region of SFRP2, which was generally regarded as a suppressor of Wnt signaling. Further quantitative reverse transcription polymerase chain reaction and Western blot experiments showed that LINC00261 upregulation potentiated the expression of SFRP2 and inhibited Wnt signaling pathway, which could both be reversely modulated by miR‐522‐3p. Taken together, our study demonstrated that LINC00261 suppressed NSCLC cells progression via sponging miR‐522‐3p and inhibiting Wnt signaling. These results supported us to better understand the pathogenic mechanism of NSCLC and revealed a potential molecular target for this fatal disease.

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Three-dimensional (3D) digital image correlation (DIC) is one of the most popular techniques used in engineering for strain and deformation measurement. However, the error analysis of 3D DIC, especially which kind of parameters dominates the error of 3D coordinate reconstruction in any kind of configuration, is still under study. In this paper, a technique that can be used for error determination of reconstruction is presented. The influence from the system calibration and image correlation to the error is theoretically analyzed. From numerical experiments of one-dimensional line and two-dimensional plane, the evaluation procedure is validated to be flexible. A typical test with standard objects is also conducted. With this technique, once a 3D DIC system is set up and images of objects with speckles and calibration boards are recorded, the error of the configuration can be immediately evaluated. The standard deviation of every point in the world coordinate can be determined by statistical analysis.