Sixty-two new Japanese encephalitis virus (JEV) isolates were obtained from mosquitoes, biting midges, human cerebrospinal fluid and human blood samples in China during [2002][2003][2004][2005]. The E and prM genes were sequenced and phylogenetic analyses were performed with 38 JEV other isolates from China and 36 JEV strains from other countries. Phylogenetic trees based on the E and prM gene sequences were similar. The results indicate that: (i) recent JEV isolates from China are divided into two genotypes, genotype 1 and genotype 3; (ii) recent JEV isolates from China are grouped into the same clusters within genotypes 1 and 3; and (iii) genotype 1 JEV strains have been isolated in China since 1979, whilst genotype 3 JEV strains were isolated before the 1970s. The results suggest that genotype 1 JEV was introduced to China around 1979 and that JEV strains belonging to genotypes 1 and 3 circulate in China.

In 2006, Tahyna virus was isolated from Culex spp. mosquitoes collected in Xinjiang, People's Republic of China. In 2007, to determine whether this virus was infecting humans, we tested serum from febrile patients. We found immunoglobulin (Ig) M and IgG against the virus, which suggests human infection in this region.

Tissue factor (TF) is a transmembrane glycoprotein to initiate blood coagulation and frequently overexpressed in a variety of tumors. Our previous study has showed that the expression of TF is upregulated and correlated with prognosis in hepatocellular carcinoma (HCC). However, the role and molecular mechanism of TF in the growth of HCC are still unclear. In vitro and in vivo functional experiments were performed to determine the effect of TF on the growth of HCC cells. A panel of biochemical assays was used to elucidate the underlying mechanisms. TF could promote the growth of HCC in vitro and in vivo by activating both ERK and AKT signaling pathways. TF induced EGFR upregualtion, and inhibition of EGFR suppressed TF-mediated HCC growth. In addition, TF protein expression was correlated with EGFR in HCC tissues. TF promotes HCC growth by upregulation of EGFR, and TF as well as EGFR may be potential therapeutic targets of HCC.

In the title complex, {[Mn(C4O4)(C10H8N2)(H2O)]·H2O}n, each MnII ion has a distorted octa­hedral coordination formed by two N atoms of a 2,2′‐bipyridine ligand, three carboxyl O atoms of three different acetyl­ene­dicarboxyl­ate ligands and one coordinated water mol­ecule. The acetyl­ene­dicarboxyl­ate ligands act in a tridentate mode connecting adjacent MnII ions and constructing a two‐dimensional structure which can be regarded as an unusual plywood‐like stacked network.

The Lunar Orbital X-ray Fluorescence Imaging Spectrometer (LOXIA) designed and constructed at the Institute of High Energy Physics of the Chinese Academy of Sciences to perform chemical composition analysis of the Moon surface will operate on-board the Chang'E-1 mission, the first Chinese lunar spacecraft to be launched in 2007. We report the main results of the calibration measurements that we have performed using the X-ray beamline of the XACT facility of INAFOsservatorio Astronomico di Palermo G.S. Vaiana to determine the quantum efficiency of the XRS detector in the soft X-rays as a function of photon energy and angle of incidence.