Objective: The aim of this study was to investigate the clinical trials of Perampanel(PER)at the First affiliated Hospital of Xiamen University (FAHXU). Recommendations have been developed for the use of Perampanel in clinical practice. Design: A retrospective single-center validation study. Setting A tertiary general hospital in Xiamen, a city located on the southeastern coast of China. Participants A total of 831 prescriptions were included for 188 patients who were treated with Perampanel. Outcome measures Record the patient's medication, including the diagnosis of the patient's disease, the dose, course of medication, and the combination of medication, analyze the characteristics of the drug population and the medication unreasonableness by comparing the drug instructions and referring to relevant literature and guidelines. Results PER was mainly used in Neurology. Epilepsy is the most common condition prescribed. There were 119 cases of inconsistent drug indications, 56 inappropriate dosing frequency, 3 inconsistent dose, and 6 inconsistent dose adjustment intervals. Conclusion There is an improper use of PER within the FAHXU. Greater attention should be paid to changes in patients'condition and observation of discomfort following medication administration. Monitoring of PER use should be further enhanced. A rational drug evaluation system should be established to promote the rational use of PER.